Ontology highlight
ABSTRACT:
SUBMITTER: Young G
PROVIDER: S-EPMC6103225 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180401 6387
The cellular processes underpinning life are orchestrated by proteins and their interactions. The associated structural and dynamic heterogeneity, despite being key to function, poses a fundamental challenge to existing analytical and structural methodologies. We used interferometric scattering microscopy to quantify the mass of single biomolecules in solution with 2% sequence mass accuracy, up to 19-kilodalton resolution, and 1-kilodalton precision. We resolved oligomeric distributions at high ...[more]