Ontology highlight
ABSTRACT:
SUBMITTER: Van Hall-Beauvais A
PROVIDER: S-EPMC6125161 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Van Hall-Beauvais Alexandra A Zhao Yi Y Urul Daniel A DA Long Marcus J C MJC Aye Yimon Y
Current protocols in chemical biology 20180807 3
T-REX (targetable reactive electrophiles and oxidants) enables electrophile targeting in living systems with high spatiotemporal precision and at single-protein-target resolution. T-REX allows functional consequences of individual electrophile signaling events to be directly linked to on-target modifications. T-REX is accomplished by expressing a HaloTagged protein of interest (POI) and introducing a Halo-targetable bioinert photocaged precursor to a reactive electrophilic signal (RES). Light ex ...[more]