Ontology highlight
ABSTRACT:
SUBMITTER: Kanaji T
PROVIDER: S-EPMC6126720 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Kanaji Taisuke T Vo My-Nuong MN Kanaji Sachiko S Zarpellon Alessandro A Shapiro Ryan R Morodomi Yosuke Y Yuzuriha Akinori A Eto Koji K Belani Rajesh R Do Minh-Ha MH Yang Xiang-Lei XL Ruggeri Zaverio M ZM Schimmel Paul P
Proceedings of the National Academy of Sciences of the United States of America 20180813 35
New mechanisms behind blood cell formation continue to be uncovered, with therapeutic approaches for hematological diseases being of great interest. Here we report an enzyme in protein synthesis, known for cell-based activities beyond translation, is a factor inducing megakaryocyte-biased hematopoiesis, most likely under stress conditions. We show an activated form of tyrosyl-tRNA synthetase (YRS<sup>ACT</sup>), prepared either by rationally designed mutagenesis or alternative splicing, induces ...[more]