Ontology highlight
ABSTRACT:
SUBMITTER: Bonomi R
PROVIDER: S-EPMC6130205 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Bonomi Robin R Popov Vadim V Laws Maxwell T MT Gelovani David D Majhi Anjoy A Shavrin Aleksandr A Lu Xin X Muzik Otto O Turkman Nashaat N Liu Renshyan R Mangner Thomas T Gelovani Juri G JG
Journal of medicinal chemistry 20180813 16
Sirtuin 1 (SIRT1) is a class III histone deacetylase that plays significant roles in the regulation of lifespan, metabolism, memory, and circadian rhythms and in the mechanisms of many diseases. However, methods of monitoring the pharmacodynamics of SIRT1-targeted drugs are limited to blood sampling because of the invasive nature of biopsies. For the noninvasive monitoring of the spatial and temporal dynamics of SIRT1 expression-activity in vivo by PET-CT-MRI, we developed a novel substrate-type ...[more]