Ontology highlight
ABSTRACT:
SUBMITTER: von Brandenstein M
PROVIDER: S-EPMC6132356 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
von Brandenstein Melanie M Bernhart Stephan H SH Pansky Andreas A Richter Claudia C Kohl Tobias T Deckert Martina M Heidenreich Axel A Stadler Peter F PF Montesinos-Rongen Manuel M Fries Jochen W U JWU
Oncotarget 20180828 67
Here, we present a miR mechanism which is active in the nucleus and is essential for the production of intron included, C-terminal truncated and biologically active proteins, like e.g. Vim3. We exemplified this mechanism by miRs, miR-15a and miR-498, which are overexpressed in clear cell renal carcinoma or oncocytoma. Both miRs directly interact with DNA in an intronic region, leading to transcriptional stop, and therefore repress the full length version of the pre-mRNA, resulting in intron incl ...[more]