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Oleanane-Type Saponins from the Roots of Ligulariopsis shichuana and Their ?-Glucosidase Inhibitory Activities.

ABSTRACT: Five new oleanane-type saponins, named ligushicosides A-E, and three known oleanane-type saponins were isolated from the roots of Ligulariopsis shichuana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast ?-glucosidase inhibitory effects and exhibited potent inhibition against ?-glucosidase, while compounds 1 and 2 showed excellent inhibitory activities. The 3-O-glycoside moiety in oleanane-type saponin is important for the ?-glucosidase inhibitory effects.

SUBMITTER: Wu HB

PROVIDER: S-EPMC6150216 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Oleanane-Type Saponins from the Roots of Ligulariopsis shichuana and Their α-Glucosidase Inhibitory Activities.

Wu Hai-Bo HB Liu Ting-Ting TT Wang Wen-Shu WS Feng Jin-Chao JC Tian Hong-Mei HM

Molecules (Basel, Switzerland) 20171117 11

Five new oleanane-type saponins, named ligushicosides A-E, and three known oleanane-type saponins were isolated from the roots of Ligulariopsis shichuana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-glucosidase inhibitory effects and exhibited potent inhibition against α-glucosidase, ...[more]

PMID: 29149016

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