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New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their ?-Glucosidase Inhibitory Activities.

ABSTRACT: In our continued investigations of the plant Caryopteris incana, five new iridoid glucosides 1-5, including two cis-trans-isomers, 3 and 4, along with six known compounds 6-11, were isolated from the n-butyl alcohol (n-BuOH) soluble fraction of whole dried material of Caryopteris incana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast ?-glucosidase inhibitory effects. Among these compounds, 4-8 and 10 exhibited potent inhibition of ?-glucosidase.

SUBMITTER: Mao XD 

PROVIDER: S-EPMC6273012 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities.

Mao Xu-Dong XD   Chou Gui-Xin GX   Zhao Sen-Miao SM   Zhang Cheng-Gang CG  

Molecules (Basel, Switzerland) 20161221 12

In our continued investigations of the plant <i>Caryopteris incana</i>, five new iridoid glucosides <b>1</b>-<b>5</b>, including two <i>cis-trans</i>-isomers, <b>3</b> and <b>4</b>, along with six known compounds <b>6</b>-<b>11</b>, were isolated from the <i>n</i>-butyl alcohol (<i>n</i>-BuOH) soluble fraction of whole dried material of <i>Caryopteris incana</i>. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospr  ...[more]

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