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Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.

ABSTRACT: We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.

SUBMITTER: Eyre DW 

PROVIDER: S-EPMC6152157 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Gonorrhoea treatment failure caused by a <i>Neisseria gonorrhoeae</i> strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.

Eyre David W DW   Sanderson Nicholas D ND   Lord Emily E   Regisford-Reimmer Natasha N   Chau Kevin K   Barker Leanne L   Morgan Markus M   Newnham Robert R   Golparian Daniel D   Unemo Magnus M   Crook Derrick W DW   Peto Tim Ea TE   Hughes Gwenda G   Cole Michelle J MJ   Fifer Helen H   Edwards Anne A   Andersson Monique I MI  

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20180701 27

We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent actio  ...[more]

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