Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6159923 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Zhang Youwen Y Chen Xiaohan X Roozbahani Golbarg M GM Guan Xiyun X
Analytical and bioanalytical chemistry 20180702 24
HIV-1 protease is essential for the life cycle of the human immunodeficiency virus (HIV), and is one of the most important clinical targets for antiretroviral therapies. In this work, we developed a graphene oxide (GO)-based fluorescence biosensing platform for the rapid, sensitive, and accurate detection of HIV-1 protease, in which fluorescent-labeled HIV-1 protease substrate peptide molecules were covalently linked to GO. In the absence of HIV-1 protease, fluorescein was effectively quenched b ...[more]