Ontology highlight
ABSTRACT:
SUBMITTER: White KI
PROVIDER: S-EPMC6160233 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
White K Ian KI Zhao Minglei M Choi Ucheor B UB Pfuetzner Richard A RA Brunger Axel T AT
eLife 20180910
The recycling of SNARE proteins following complex formation and membrane fusion is an essential process in eukaryotic trafficking. A highly conserved AAA+ protein, NSF (<i>N</i>-ethylmaleimide sensitive factor) and an adaptor protein, SNAP (soluble NSF attachment protein), disassemble the SNARE complex. We report electron-cryomicroscopy structures of the complex of NSF, αSNAP, and the full-length soluble neuronal SNARE complex (composed of syntaxin-1A, synaptobrevin-2, SNAP-25A) in the presence ...[more]