Facile Synthesis of ?-Lactoglobulin-Functionalized Reduced Graphene Oxide and Trimetallic PtAuPd Nanocomposite for Electrochemical Sensing.

ABSTRACT: The use of graphene has leapt forward the materials field and the functional modification of graphene has not stopped. In this work, ?-lactoglobulin (BLG) was used to functionalize reduced graphene oxide (RGO) based on its amphiphilic properties. Also, trimetallic PtAuPd nanoparticles were reduced to the surface of BLG-functionalized RGO and formed BLG-PtAuPd-RGO nanocomposite using facile synthesis. Transmission electron microscopy, energy-dispersive X-ray spectroscopy and Fourier transform infrared spectra were used to characterize the nanocomposite. Electrocatalytic analysis was evaluated through cyclic voltammetry and chronoamperometry methods. We developed a glucose sensor by fabricating GOD-BLG-PtAuPd-RGO/glassy carbon (GC) electrode. It presented a remarkable sensitivity of 63.29 ?A mM^-1 cm^-2 (4.43 ?A mM^-1), a wider linear range from 0.005 to 9 mM and a lower detection limit of 0.13 ?M (S/N = 3). Additionally, the glucose sensor exhibited excellent testing capability in human serum samples.

SUBMITTER: Han B 

PROVIDER: S-EPMC6165462 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature