Reduced graphene oxide-supported methylene blue nanocomposite as a glucose oxidase-mimetic for electrochemical glucose sensing.

ABSTRACT: In this paper, a hybrid nanocomposite (MB-rGO) was synthesized based on the π-π stacking interactions between methylene blue (MB) and reduced graphene oxide (rGO). The as-synthesized nanocomposite was characterized by SEM, TEM, XRD, FTIR, UV-vis and XPS spectra. UV-vis spectroscopy and electrochemical tests suggested the MB-rGO modified on the electrode exhibited glucose oxidase-mimetic catalytic activity towards glucose, and displayed excellent electrocatalytic performance for electrochemical detection of glucose with a wide linear range from 1.04 to 17.44 mM, a low detection limit of 45.8 μM and a large sensitivity of 13.08 μA mM^-1 cm^-2. The proposed glucose sensor also showed high stability, reproducibility and good abilities of anti-interference to dopamine, ascorbic acid and uric acid. Moreover, the modified electrode was used to determine glucose concentration in human blood serum samples with satisfactory results.

SUBMITTER: Yang S 

PROVIDER: S-EPMC9086296 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature