Ontology highlight
ABSTRACT:
SUBMITTER: Goovaerts T
PROVIDER: S-EPMC6175939 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Goovaerts Tine T Steyaert Sandra S Vandenbussche Chari A CA Galle Jeroen J Thas Olivier O Van Criekinge Wim W De Meyer Tim T
Nature communications 20181008 1
Genomic imprinting plays an important role in growth and development. Loss of imprinting (LOI) has been found in cancer, yet systematic studies are impeded by data-analytical challenges. We developed a methodology to detect monoallelically expressed loci without requiring genotyping data, and applied it on The Cancer Genome Atlas (TCGA, discovery) and Genotype-Tissue expression project (GTEx, validation) breast tissue RNA-seq data. Here, we report the identification of 30 putatively imprinted ge ...[more]