Ontology highlight
ABSTRACT:
SUBMITTER: Gruba N
PROVIDER: S-EPMC6187398 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20180828 10
Although the mosquito-borne Zika virus was discovered in the late 1940s of the 20th century, for years it was neglected, as the disease in humans was rare and relatively mild. Viral NS2B-NS3 protease is essential for virus replication, and except for maturation of viral proteins, it also modulates the infection microenvironment to facilitate virus invasion. Here, we report the combinatorial chemistry approach for the synthesis of internally quenched substrates of the Zika virus NS2B-NS3 protease ...[more]