Ontology highlight
ABSTRACT:
SUBMITTER: Zou W
PROVIDER: S-EPMC6193023 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Zou Wenjuan W Fu Jiajun J Zhang Haining H Du Kang K Huang Wenming W Yu Junwei J Li Shitian S Fan Yuedan Y Baylis Howard A HA Gao Shangbang S Xiao Rui R Ji Wei W Kang Lijun L Xu Tao T
Nature communications 20181017 1
How neurons are capable of decoding stimulus intensity and translate this information into complex behavioral outputs is poorly defined. Here, we demonstrate that the C. elegans interneuron AIB regulates two types of behaviors: reversal initiation and feeding suppression in response to different concentrations of quinine. Low concentrations of quinine are decoded in AIB by a low-threshold, fast-inactivation glutamate receptor GLR-1 and translated into reversal initiation. In contrast, high conce ...[more]