Ontology highlight
ABSTRACT:
SUBMITTER: Kida H
PROVIDER: S-EPMC6212438 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Kida Hitoshi H Fukutani Yosuke Y Mainland Joel D JD de March Claire A CA Vihani Aashutosh A Li Yun Rose YR Chi Qiuyi Q Toyama Akemi A Liu Linda L Kameda Masaharu M Yohda Masafumi M Matsunami Hiroaki H
Nature communications 20181101 1
Olfactory systems have evolved the extraordinary capability to detect and discriminate volatile odorous molecules (odorants) in the environment. Fundamentally, this process relies on the interaction of odorants and their cognate olfactory receptors (ORs) encoded in the genome. Here, we conducted a cell-based screen using over 800 mouse ORs against seven odorants, resulting in the identification of a set of high-affinity and/or broadly-tuned ORs. We then test whether heterologously expressed ORs ...[more]