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Euphosantianane E-G: Three New Premyrsinane Type Diterpenoids from Euphorbia sanctae-catharinae with Contribution to Chemotaxonomy.


ABSTRACT: Euphorbia species were widely used in traditional medicines for the treatment of several diseases. From the aerial parts of Egyptian endemic plant, Euphorbia sanctae-catharinae, three new premyrsinane diterpenoids, namely, euphosantianane E-G (1-3), alongside four known triterpenes, 9,19-cyclolanostane-3β,24S-diol (4), 25-methoxycycloartane-3β,24S-diol (5), 25-methylenecycloartan-3β,24R-diol (6), and 25-methylenecycloartan-3β,24S-diol (7), were isolated and identified. The chemical structures were proven depending upon spectroscopic analysis, including FTIR, HRFABMS, and 1D/2D-NMR. The chemotaxonomic significance of the isolated compounds, especially diterpenes from E. sanctae-catharinae compared to those documented from different Euphorbia species was also studied via agglomerative hierarchical clustering (AHC). The Egyptian endemic Euphorbia sanctae-catharina was grouped with E. bupleuroides, E. fidjiana, E. fischeriana, E. pithyusa subsp. cupanii, E. prolifera, and E. seguieriana, where myrsinol diterpenoids were the characteristic compounds.

SUBMITTER: Elshamy AI 

PROVIDER: S-EPMC6651875 | biostudies-other | 2019 Jun

REPOSITORIES: biostudies-other

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Euphosantianane E-G: Three New Premyrsinane Type Diterpenoids from <i>Euphorbia sanctae-catharinae</i> with Contribution to Chemotaxonomy.

Elshamy Abdelsamed I AI   Mohamed Tarik A TA   Al-Rowaily Saud L SL   Abd-ElGawad Ahmed M AM   Dar Basharat A BA   Shahat Abdelaaty A AA   Hegazy Mohamed-Elamir F MF  

Molecules (Basel, Switzerland) 20190629 13


<i>Euphorbia</i> species were widely used in traditional medicines for the treatment of several diseases. From the aerial parts of Egyptian endemic plant, <i>Euphorbia sanctae-catharinae</i>, three new premyrsinane diterpenoids, namely, euphosantianane E-G (<b>1</b>-<b>3</b>), alongside four known triterpenes, 9,19-cyclolanostane-3β,24<i>S</i>-diol (<b>4</b>), 25-methoxycycloartane-3β,24<i>S</i>-diol (<b>5</b>), 25-methylenecycloartan-3β,24<i>R</i>-diol (<b>6</b>), and 25-methylenecycloartan-3β,  ...[more]

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