Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma.
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ABSTRACT:
SUBMITTER: Stepanov AV
PROVIDER: S-EPMC6235538 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma.
Stepanov Alexey V AV Markov Oleg V OV Chernikov Ivan V IV Gladkikh Daniil V DV Zhang Hongkai H Jones Teresa T Sen'kova Alexandra V AV Chernolovskaya Elena L EL Zenkova Marina A MA Kalinin Roman S RS Rubtsova Maria P MP Meleshko Alexander N AN Genkin Dmitry D DD Belogurov Alexey A AA Xie Jia J Gabibov Alexander G AG Lerner Richard A RA
Science advances 20181114 11
We report the development of a novel platform to enhance the efficacy and safety of follicular lymphoma (FL) treatment. Since lymphoma is a clonal malignancy of a diversity system, every tumor has a different antibody on its cell surface. Combinatorial autocrine-based selection is used to rapidly identify specific ligands for these B cell receptors on the surface of FL tumor cells. The selected ligands are used in a chimeric antigen receptor T cell (CAR-T) format for redirection of human cytotox ...[more]
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