Ontology highlight
ABSTRACT:
SUBMITTER: Gruber DR
PROVIDER: S-EPMC6237784 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Gruber David R DR Toner Joanna J JJ Miears Heather L HL Shernyukov Andrey V AV Kiryutin Alexey S AS Lomzov Alexander A AA Endutkin Anton V AV Grin Inga R IR Petrova Darya V DV Kupryushkin Maxim S MS Yurkovskaya Alexandra V AV Johnson Eric C EC Okon Mark M Bagryanskaya Elena G EG Zharkov Dmitry O DO Smirnov Serge L SL
Nucleic acids research 20181101 20
DNA damage can affect various regulatory elements of the genome, with the consequences for DNA structure, dynamics, and interaction with proteins remaining largely unexplored. We used solution NMR spectroscopy, restrained and free molecular dynamics to obtain the structures and investigate dominant motions for a set of DNA duplexes containing CpG sites permuted with combinations of 5-methylcytosine (mC), the primary epigenetic base, and 8-oxoguanine (oxoG), an abundant DNA lesion. Guanine oxidat ...[more]