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Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae with Chromosomally Carried bla NDM-1.

ABSTRACT: We report here Klebsiella pneumoniae strains carrying chromosomal bla NDM-1 in Thailand. The genomes of these two isolates include a 160-kbp insertion containing bla NDM-1, which is almost identical to that in the IncHI1B-like plasmid. Further analysis indicated that IS5-mediated intermolecular transposition and Tn3 transposase-mediated homologous recombination resulted in the integration of bla NDM-1 into the chromosome from an IncHI1B-like plasmid. The spread of this type of carbapenem-resistant Enterobacteriaceae may threaten public health and warrants further monitoring.

SUBMITTER: Sakamoto N 

PROVIDER: S-EPMC6256778 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae with Chromosomally Carried <i>bla</i><sub>NDM-1</sub>.

Sakamoto Noriko N   Akeda Yukihiro Y   Sugawara Yo Y   Takeuchi Dan D   Motooka Daisuke D   Yamamoto Norihisa N   Laolerd Warawut W   Santanirand Pitak P   Hamada Shigeyuki S  

Antimicrobial agents and chemotherapy 20181126 12

We report here <i>Klebsiella pneumoniae</i> strains carrying chromosomal <i>bla</i><sub>NDM-1</sub> in Thailand. The genomes of these two isolates include a 160-kbp insertion containing <i>bla</i><sub>NDM-1</sub>, which is almost identical to that in the IncHI1B-like plasmid. Further analysis indicated that IS<i>5</i>-mediated intermolecular transposition and Tn<i>3</i> transposase-mediated homologous recombination resulted in the integration of <i>bla</i><sub>NDM-1</sub> into the chromosome fro  ...[more]

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