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Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae with Chromosomally Carried bla NDM-1.

ABSTRACT: We report here Klebsiella pneumoniae strains carrying chromosomal bla NDM-1 in Thailand. The genomes of these two isolates include a 160-kbp insertion containing bla NDM-1, which is almost identical to that in the IncHI1B-like plasmid. Further analysis indicated that IS5-mediated intermolecular transposition and Tn3 transposase-mediated homologous recombination resulted in the integration of bla NDM-1 into the chromosome from an IncHI1B-like plasmid. The spread of this type of carbapenem-resistant Enterobacteriaceae may threaten public health and warrants further monitoring.

SUBMITTER: Sakamoto N

PROVIDER: S-EPMC6256778 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae with Chromosomally Carried blaNDM-1.

Sakamoto Noriko N Akeda Yukihiro Y Sugawara Yo Y Takeuchi Dan D Motooka Daisuke D Yamamoto Norihisa N Laolerd Warawut W Santanirand Pitak P Hamada Shigeyuki S

Antimicrobial agents and chemotherapy 20181126 12

We report here Klebsiella pneumoniae strains carrying chromosomal blaNDM-1 in Thailand. The genomes of these two isolates include a 160-kbp insertion containing blaNDM-1, which is almost identical to that in the IncHI1B-like plasmid. Further analysis indicated that IS5-mediated intermolecular transposition and Tn3 transposase-mediated homologous recombination resulted in the integration of blaNDM-1 into the chromosome fro ...[more]

PMID: 30323033

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