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Cu-Catalyzed Decarboxylative Borylation.

ABSTRACT: A simple method for the conversion of carboxylic acids to boronic esters via redox-active esters (RAEs) is reported using copper catalysis. The scope of this transformation is broad, and compared with the known protocols available, it represents the most inexpensive, rapid, and operationally simple option. In addition to a full exploration of the scope, a kinetic study was performed to elucidate substrate and reagent concentration dependences.

SUBMITTER: Wang J

PROVIDER: S-EPMC6257631 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Cu-Catalyzed Decarboxylative Borylation.

Wang Jie J Shang Ming M Lundberg Helena H Feu Karla S KS Hecker Scott J SJ Qin Tian T Blackmond Donna G DG Baran Phil S PS

ACS catalysis 20180913 10

A simple method for the conversion of carboxylic acids to boronic esters via redox-active esters (RAEs) is reported using copper catalysis. The scope of this transformation is broad, and compared with the known protocols available, it represents the most inexpensive, rapid, and operationally simple option. In addition to a full exploration of the scope, a kinetic study was performed to elucidate substrate and reagent concentration dependences. ...[more]

PMID: 30505624

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