Stimulated echo based mapping (STEM) of T₁ , T₂ , and apparent diffusion coefficient: validation and protocol optimization.

ABSTRACT:

Purpose

To present a stimulated-echo based mapping (STEM) approach for simultaneous T₁ , T₂ , and ADC mapping.

Methods

Diffusion-weighted stimulated-echo images with various combinations of mixing time (TM), TE, and b-value were acquired to enable simultaneous mapping of T₁ , T₂ , and ADC. The proposed STEM method was performed by densely sampling the TM-TE-b space in a phantom and in brain and prostate of healthy volunteers. T₁ , T₂ , and ADC from STEM were compared to reference mapping methods. Additionally, protocol optimization was performed to enable rapid STEM acquisition within 2 min by sparsely sampling the TM-TE-b space. The T₁ , T₂ , and ADC measurements from rapid acquisitions

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6258304 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature