Ontology highlight
ABSTRACT:
SUBMITTER: Germany EM
PROVIDER: S-EPMC6262775 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Germany Edward M EM Zahayko Nataliya N Huebsch Mason L ML Fox Jennifer L JL Prahlad Veena V Khalimonchuk Oleh O
Journal of cell science 20181121 22
Mitochondrial functions are critical for cellular physiology; therefore, several conserved mechanisms are in place to maintain the functional integrity of mitochondria. However, many of the molecular details and components involved in ensuring mitochondrial fidelity remain obscure. Here, we identify a novel role for the conserved mitochondrial AAA ATPase Afg1 in mediating mitochondrial protein homeostasis during aging and in response to various cellular challenges. <i>Saccharomyces cerevisiae</i ...[more]