Dataset Information
Synthesis of C?-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular ?-Arylation of Amides.
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ABSTRACT:
SUBMITTER: He W
PROVIDER: S-EPMC6274209 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Synthesis of C₂-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides.
Molecules (Basel, Switzerland) 20160608 6
A series of C₂-symmetric chiral benzimidazolium salts, the precursor of N-heterocyclic carbene ligands, were designed and synthesized from 1,2-dibromobenzene. In situ prepared corresponding carbenes were tested in the asymmetric palladium-catalyzed intramolecular α-arylation of amides, affording chiral diarylmethanols with high yields and moderate enantioselectivities. ...[more]