Dataset Information
Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing ?,?-Unsaturated ?-Lactams.
Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Q
PROVIDER: S-EPMC5993423 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Publications
Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams.
Journal of the American Chemical Society 20180516 21
In this Communication, we describe the construction of chiral α,β-unsaturated δ-lactams, widely used as pharmacophores, in high yields and excellent enantioselectivities using an oxidative relay Heck arylation reaction. This strategy also allows facile access to 7-substituted α,β-unsaturated ε-lactam products and δ-lactams containing a tetrasubstituted nitrogen-bearing stereocenter. ...[more]