Urine biomarkers of chronic kidney damage and renal functional decline in childhood-onset systemic lupus erythematosus.

ABSTRACT: OBJECTIVES:To delineate urine biomarkers that reflect kidney structural damage and predict renal functional decline in pediatric lupus nephritis (LN). METHODS:In this prospective study, we evaluated kidney biopsies and urine samples of 89 patients with pediatric LN. Urinary levels of 10 biomarkers [adiponectin, ceruloplasmin, kidney injury molecule-1, monocyte chemotactic protein-1, neutrophil gelatinase-associated lipocalin, osteopontin, transforming growth factor-ß (TGFß), vitamin-D binding protein, liver fatty acid binding protein (LFABP), and transferrin] were measured. Regression analysis was used to identify individual and combinations of biomarkers that determine LN damage status [NIH-chronicity index (NIH-CI) score ??1 vs. ??2] both individually and in combination, and biomarker levels were compared for patients with vs. without renal functional decline, i.e., a 20% reduction of the glomerular filtration rate (GFR) within 12 months of a kidney biopsy. RESULTS:Adiponectin, LFABP, and osteopontin levels differed significantly with select histological damage features considered in the NIH-CI. The GFR was associated with NIH-CI scores [Pearson correlation coefficient (r)?=?-?0.49; p??0.05). Similar to the GFR [area under the ROC curve (AUC)?=?0.72; p?

SUBMITTER: Brunner HI 

PROVIDER: S-EPMC6294330 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature