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Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation

ABSTRACT: Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation

PROVIDER: PRJNA484184 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7638380.fastq.gz	Fastqsanger.gz
	SRR7638381.fastq.gz	Fastqsanger.gz
	SRR7638382.fastq.gz	Fastqsanger.gz
	SRR7638383.fastq.gz	Fastqsanger.gz
	SRR7638384.fastq.gz	Fastqsanger.gz

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Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Ribo-seq]

Project description:Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Ribo-seq]

| PRJNA484185 | ENA

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Illumina array]

Project description:Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Illumina array]

| PRJNA484186 | ENA

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [iCLIP-seq]

Project description:Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [iCLIP-seq]

| PRJNA484188 | ENA

Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation.

Project description:Syndesmos (SDOS) is a functionally poorly characterized protein that directly interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS directly binds RNA in living cells. Combining individual gene expression profiling, nucleotide crosslinking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS. Among them, we identify a small subset of mRNAs responsible for the biogenesis of primary cilium that have been linked to developmental and degenerative diseases, known as ciliopathies, and cancer. We discover that SDOS binds and regulates the translation of several of these mRNAs, controlling cilia development.

| S-EPMC6294507 | biostudies-literature

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [iCLIP-seq]

Project description:We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS binds directly RNA in living cells. Combining individual gene expression profiling, nucleotide cross-linking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS.

2018-09-26 | GSE118049 | GEO

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Illumina array]

2018-09-26 | GSE118035 | GEO

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Ribo-seq]

Project description:We show here that NUDT16L1/TIRR/Syndesmos (SDOS) interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS binds directly RNA in living cells. Combining individual gene expression profiling, nucleotide cross-linking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS.

2018-09-26 | GSE117998 | GEO

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-09-26 | GSE118050 | GEO

SMPD4 mediated sphingolipid metabolism regulates brain and primary cilia development

Project description:SMPD4 (neutral sphingomyelinase-3/nSMase3) has recently been shown to be a new cause of microcephaly in a cohort of twenty-three pediatric patients. The function of nSMases in brain development and how SMPD4 variants cause human microcephaly and cerebellar hypoplasia was previously unknown.We developed an iPSC model to complement our mouse study. We found iPSC models from human SMPD4 patient and CRISPR/Cas9-induced SMPD4 knockout lines demonstrate a proliferation defect, increased cell death, loss of neural progenitors, and shortened primary cilia. Treatment with exogenous ceramide significantly rescues the cilia defect. SMPD4 patient and knockout cells have altered WNT signaling. We provide evidence that SMPD4 controls brain development by providing ceramide for primary ciliogenesis, suggesting a novel therapeutic strategy for SMPD4 mediated disease.

2023-12-24 | GSE250472 | GEO

STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer

Project description:Our research showed that primary cilia was reduced in human bladder cancer (BLCA) cells, and PC deficiency promote cell proliferation. However, the concrete mechanisms remain unknown. SCL/TAL1 interrupting locus (STIL), a PC-related protein, was screened in our previous study and could influence the cell cycle by regulating PC in tumor cells. To elucidate the function of STIL for PC to explore the underlying mechanism of PC in BLCA, we establisded siNC and siSTIL EJ cells.

2023-03-31 | GSE211563 | GEO

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