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Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea.


ABSTRACT: Nineteen metabolites with diverse structures, including the rare pyrroloindoline alkaloid verrupyrroloindoline (1), the unprecedented highly fused benzosesquiterpenoid verrubenzospirolactone (2), the new asteriscane-type sesquiterpenoid 10-deoxocapillosanane D (3), and the two new cyclopentenone derivatives (4S*,5S*)-4-hydroxy-5-(hydroxymethyl)-2,3-dimethyl-4-pentylcyclopent-2-en-1-one (4) and (S)-4-hydroxy-5-methylene-2,3-dimethyl-4-pentylcyclopent-2-en-1-one (5), were isolated from a South China Sea collection of the soft coral Sinularia verruca. Eleven previously described marine metabolites (7-15, 18, and 19) were also obtained as well as three new EtOH-adduct artifacts (6, 16, and 17). The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 4, 5, and 16 showed protection against the cytopathic effects of HIV-1 infection with EC50 values of 5.8-34 ?M, and 4, 6, and 16 exhibited inhibition against LPS-induced NO production with IC50 values of 24-28 ?M.

SUBMITTER: Yuan W 

PROVIDER: S-EPMC6328250 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea.

Yuan Weiping W   Cheng Shimiao S   Fu Weitao W   Zhao Min M   Li Xiubao X   Cai Yuepiao Y   Dong Jianyong J   Huang Kexin K   Gustafson Kirk R KR   Yan Pengcheng P  

Journal of natural products 20160324 4


Nineteen metabolites with diverse structures, including the rare pyrroloindoline alkaloid verrupyrroloindoline (1), the unprecedented highly fused benzosesquiterpenoid verrubenzospirolactone (2), the new asteriscane-type sesquiterpenoid 10-deoxocapillosanane D (3), and the two new cyclopentenone derivatives (4S*,5S*)-4-hydroxy-5-(hydroxymethyl)-2,3-dimethyl-4-pentylcyclopent-2-en-1-one (4) and (S)-4-hydroxy-5-methylene-2,3-dimethyl-4-pentylcyclopent-2-en-1-one (5), were isolated from a South Chi  ...[more]

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