Metabolites from the Paracel Islands Soft Coral Sinularia cf. molesta.

ABSTRACT: Five new oxygenated sesquiterpenes, molestins A?D (1, 3?5) and epi-gibberodione (2), three new cyclopentenone derivatives, ent-sinulolides C, D, and F ((+)-9?(+)-11), one new butenolide derivative, ent-sinulolide H ((+)-13), and one new cembranolide, molestin E (14), together with 14 known related metabolites (6?8, (?)-9?(?)-11, (±)-12, (?)-13, 15?19) were isolated from the Paracel Islands soft coral Sinularia cf. molesta. The structures and absolute configurations were elucidated based on comprehensive spectroscopic analyses, quantum chemical calculations, and comparison with the literature data. Compound 5 is the first example of a norsesquiterpene with a de-isopropyl guaiane skeleton isolated from the genus Sinularia. Molestin E (14) exhibited cytotoxicities against HeLa and HCT-116 cell lines with IC50 values of 5.26 and 8.37 ?M, respectively. Compounds 4, 5, and 8 showed significant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 218, 344, and 1.24 ?M, respectively.

SUBMITTER: Chu MJ 

PROVIDER: S-EPMC6317055 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature