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Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis.

ABSTRACT: Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6?14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inflammatory activities of the isolates were investigated, and the results showed that dehydrosinulariolide (7) and 11-epi-sinulariolide acetate (8) exhibited cytotoxicity toward a limited panel of cancer cell lines and 14-deoxycrassin (9) displayed anti-inflammatory activity by inhibition of superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils.

SUBMITTER: Wu CH

PROVIDER: S-EPMC6117644 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis.

Wu Chia-Hua CH Chao Chih-Hua CH Huang Tzu-Zin TZ Huang Chiung-Yao CY Hwang Tsong-Long TL Dai Chang-Feng CF Sheu Jyh-Horng JH

Marine drugs 20180809 8

Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6⁻14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inf ...[more]

PMID: 30096866

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