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Sarcophyolides B-E, new cembranoids from the soft coral Sarcophyton elegans.


ABSTRACT: Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells.

SUBMITTER: Xi Z 

PROVIDER: S-EPMC3801120 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Sarcophyolides B-E, new cembranoids from the soft coral Sarcophyton elegans.

Xi Zhifang Z   Bie Wei W   Chen Wei W   Liu Dong D   van Ofwegen Leen L   Proksch Peter P   Lin Wenhan W  

Marine drugs 20130826 9


Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells. ...[more]

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