Liver DNA methylation of FADS2 associates with FADS2 genotype.
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ABSTRACT:
SUBMITTER: Walle P
PROVIDER: S-EPMC6337806 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
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Liver DNA methylation of FADS2 associates with FADS2 genotype.
Walle Paula P Männistö Ville V de Mello Vanessa Derenji VD Vaittinen Maija M Perfilyev Alexander A Hanhineva Kati K Ling Charlotte C Pihlajamäki Jussi J
Clinical epigenetics 20190117 1
<h4>Background</h4>Non-alcoholic fatty liver disease has been associated with increased mRNA expression of FADS2 in the liver and estimated activity of delta-6 desaturase in serum, encoded by the FADS2 gene. Since DNA methylation in the FADS1/2/3 gene cluster has been previously linked with genetic variants and desaturase activities, we now aimed to discover factors regulating DNA methylation of the CpG sites annotated to FADS1/2 genes.<h4>Methods</h4>DNA methylation levels in the CpG sites anno ...[more]
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