Ontology highlight
ABSTRACT:
SUBMITTER: Prinslow EA
PROVIDER: S-EPMC6353594 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Prinslow Eric A EA Stepien Karolina P KP Pan Yun-Zu YZ Xu Junjie J Rizo Josep J
eLife 20190118
Neurotransmitter release requires formation of trans-SNARE complexes between the synaptic vesicle and plasma membranes, which likely underlies synaptic vesicle priming to a release-ready state. It is unknown whether Munc18-1, Munc13-1, complexin-1 and synaptotagmin-1 are important for priming because they mediate trans-SNARE complex assembly and/or because they prevent trans-SNARE complex disassembly by NSF-αSNAP, which can lead to de-priming. Here we show that trans-SNARE complex formation in t ...[more]