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Contemporary patient-tailored treatment strategies against high risk and relapsed or refractory multiple myeloma.

ABSTRACT: Recurrence of disease due to chemotherapy drug resistance remains a major obstacle to a more successful survival outcome of multiple myeloma (MM). Overcoming drug resistance and salvaging patients with relapsed and/or refractory (R/R) MM is an urgent and unmet medical need. Several new personalized treatment strategies have been developed against molecular targets to overcome this drug resistance. There are several targeted therapeutics with anti-MM activity in clinical pipeline, including inhibitors of anti-apoptotic proteins, monoclonal antibodies, antibody-drug conjugates, bispecific antibodies, fusion proteins, and various cell therapy platforms. For example, B-cell maturation antigen (BCMA)-specific CAR-T cell platforms showed promising activity in heavily pretreated R/R MM patients. Therefore, there is renewed hope for high-risk as well as R/R MM patients in the era of personalized medicine.

SUBMITTER: Uckun FM

PROVIDER: S-EPMC6354702 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Contemporary patient-tailored treatment strategies against high risk and relapsed or refractory multiple myeloma.

Uckun Fatih M FM Qazi Sanjive S Demirer Taner T Champlin Richard E RE

EBioMedicine 20181210

Recurrence of disease due to chemotherapy drug resistance remains a major obstacle to a more successful survival outcome of multiple myeloma (MM). Overcoming drug resistance and salvaging patients with relapsed and/or refractory (R/R) MM is an urgent and unmet medical need. Several new personalized treatment strategies have been developed against molecular targets to overcome this drug resistance. There are several targeted therapeutics with anti-MM activity in clinical pipeline, including inhib ...[more]

PMID: 30545798

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