Ontology highlight
ABSTRACT:
SUBMITTER: Moller K
PROVIDER: S-EPMC6355916 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Möller Katrin K Sigurbjornsdottir Sara S Arnthorsson Asgeir O AO Pogenberg Vivian V Dilshat Ramile R Fock Valerie V Brynjolfsdottir Solveig H SH Bindesboll Christian C Bessadottir Margret M Ogmundsdottir Helga M HM Simonsen Anne A Larue Lionel L Wilmanns Matthias M Thorsson Vesteinn V Steingrimsson Eirikur E Ogmundsdottir Margret H MH
Scientific reports 20190131 1
The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes known to be important in melanoma. Here we show that MITF binds the CLEAR-box element in the promoters of lysosomal and autophagosomal genes in melanocytes and melanoma cells. The crystal structure of MITF bound to the CLEAR-box reveals how the palindromic nature of this motif in ...[more]