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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia.

ABSTRACT: Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N?=?2562-3468). We observed a genome-wide significant effect (p?

SUBMITTER: Gialluisi A 

PROVIDER: S-EPMC6370792 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia.

Gialluisi Alessandro A   Andlauer Till F M TFM   Mirza-Schreiber Nazanin N   Moll Kristina K   Becker Jessica J   Hoffmann Per P   Ludwig Kerstin U KU   Czamara Darina D   St Pourcain Beate B   Brandler William W   Honbolygó Ferenc F   Tóth Dénes D   Csépe Valéria V   Huguet Guillaume G   Morris Andrew P AP   Hulslander Jacqueline J   Willcutt Erik G EG   DeFries John C JC   Olson Richard K RK   Smith Shelley D SD   Pennington Bruce F BF   Vaessen Anniek A   Maurer Urs U   Lyytinen Heikki H   Peyrard-Janvid Myriam M   Leppänen Paavo H T PHT   Brandeis Daniel D   Bonte Milene M   Stein John F JF   Talcott Joel B JB   Fauchereau Fabien F   Wilcke Arndt A   Francks Clyde C   Bourgeron Thomas T   Monaco Anthony P AP   Ramus Franck F   Landerl Karin K   Kere Juha J   Scerri Thomas S TS   Paracchini Silvia S   Fisher Simon E SE   Schumacher Johannes J   Nöthen Markus M MM   Müller-Myhsok Bertram B   Schulte-Körne Gerd G  

Translational psychiatry 20190211 1

Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the  ...[more]

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