Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol.
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ABSTRACT:
SUBMITTER: Cassiano C
PROVIDER: S-EPMC6375844 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol.
Cassiano Chiara C Esposito Roberta R Tosco Alessandra A Casapullo Agostino A Mozzicafreddo Matteo M Tringali Corrado C Riccio Raffaele R Monti Maria Chiara MC
Frontiers in chemistry 20190208
Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Imp ...[more]
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