Towards functional characterization of archaeal genomic dark matter.
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ABSTRACT:
SUBMITTER: Makarova KS
PROVIDER: S-EPMC6393860 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Towards functional characterization of archaeal genomic dark matter.
Makarova Kira S KS Wolf Yuri I YI Koonin Eugene V EV
Biochemical Society transactions 20190201 1
A substantial fraction of archaeal genes, from ∼30% to as much as 80%, encode 'hypothetical' proteins or genomic 'dark matter'. Archaeal genomes typically contain a higher fraction of dark matter compared with bacterial genomes, primarily, because isolation and cultivation of most archaea in the laboratory, and accordingly, experimental characterization of archaeal genes, are difficult. In the present study, we present quantitative characteristics of the archaeal genomic dark matter and discuss ...[more]
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