Ontology highlight
ABSTRACT:
SUBMITTER: Ho YY
PROVIDER: S-EPMC5133497 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Ho Yen-Yi YY Guan Weihua W O'Connell Michael M Basu Saonli S
BMC proceedings 20161018 Suppl 7
<h4>Background</h4>Genetic association studies aim to test for disease or trait association with genetic variants, either throughout the human genome or in regions of interest. However, for most diseases and traits, the combined effects of associated genetic variants explain only a small proportion of the genetic variation. This "missing heritability" may be a result of the small effects of common variants considered in the genetic association studies. Rare variants may also play an important ro ...[more]