Ontology highlight
ABSTRACT:
SUBMITTER: Ziska A
PROVIDER: S-EPMC6451349 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ziska Anke A Tatzelt Jörg J Dudek Johanna J Paton Adrienne W AW Paton James C JC Zimmermann Richard R Haßdenteufel Sarah S
Biology open 20190305 3
The Sec61-complex as a dynamic polypeptide-conducting channel mediates protein transport into the human endoplasmic reticulum (ER) with the help of additional components. ER membrane resident Hsp40-type co-chaperone Sec63 as well as the ER lumenal Hsp70-type chaperone BiP were proposed to facilitate channel opening in a precursor-specific fashion. Here, we report on their rules of engagement in ER import of the prion protein (PrP) by addressing sixteen PrP-related variants which differ in their ...[more]