Ontology highlight
ABSTRACT:
SUBMITTER: Hiester BG
PROVIDER: S-EPMC6466620 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Hiester Brian G BG Bourke Ashley M AM Sinnen Brooke L BL Cook Sarah G SG Gibson Emily S ES Smith Katharine R KR Kennedy Matthew J MJ
Cell reports 20171101 8
The repertoire and abundance of proteins displayed on the surface of neuronal dendrites are tuned by regulated fusion of recycling endosomes (REs) with the dendritic plasma membrane. While this process is critical for neuronal function and plasticity, how synaptic activity drives RE fusion remains unexplored. We demonstrate a multistep fusion mechanism that requires Ca<sup>2+</sup> from distinct sources. NMDA receptor Ca<sup>2+</sup> initiates RE fusion with the plasma membrane, while L-type vol ...[more]