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Advances in chronic cerebral circulation insufficiency.


ABSTRACT: Chronic cerebral circulation insufficiency (CCCI) may not be an independent disease; rather, it is a pervasive state of long-term cerebral blood flow insufficiency caused by a variety of etiologies, and considered to be associated with either occurrence or recurrence of ischemic stroke, vascular cognitive impairment, and development of vascular dementia, resulting in disability and mortality worldwide. This review summarizes the features and recent progress of CCCI, mainly focusing on epidemiology, experimental research, pathophysiology, etiology, clinical manifestations, imaging presentation, diagnosis, and potential therapeutic regimens. Some research directions are briefly discussed as well.

SUBMITTER: Zhou D 

PROVIDER: S-EPMC6489997 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Advances in chronic cerebral circulation insufficiency.

Zhou Da D   Meng Ran R   Li Si-Jie SJ   Ya Jing-Yuan JY   Ding Jia-Yue JY   Shang Shu-Ling SL   Ding Yu-Chuan YC   Ji Xun-Ming XM  

CNS neuroscience & therapeutics 20171115 1


Chronic cerebral circulation insufficiency (CCCI) may not be an independent disease; rather, it is a pervasive state of long-term cerebral blood flow insufficiency caused by a variety of etiologies, and considered to be associated with either occurrence or recurrence of ischemic stroke, vascular cognitive impairment, and development of vascular dementia, resulting in disability and mortality worldwide. This review summarizes the features and recent progress of CCCI, mainly focusing on epidemiolo  ...[more]

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