Ontology highlight
ABSTRACT:
SUBMITTER: Solinski HJ
PROVIDER: S-EPMC6490177 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Solinski Hans Jürgen HJ Kriegbaum Mette C MC Tseng Pang-Yen PY Earnest Thomas W TW Gu Xinglong X Barik Arnab A Chesler Alexander T AT Hoon Mark A MA
Cell reports 20190301 13
Itch is an unpleasant skin sensation that can be triggered by exposure to many chemicals, including those released by mast cells. The natriuretic polypeptide b (Nppb)-expressing class of sensory neurons, when activated, elicits scratching responses in mice, but it is unclear which itch-inducing agents stimulate these cells and the receptors involved. Here, we identify receptors expressed by Nppb neurons and demonstrate the functional importance of these receptors as sensors of endogenous prurito ...[more]