Ontology highlight
ABSTRACT:
SUBMITTER: Mazibuko-Mbeje SE
PROVIDER: S-EPMC6497260 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Mazibuko-Mbeje Sithandiwe E SE Dludla Phiwayinkosi V PV Johnson Rabia R Joubert Elizabeth E Louw Johan J Ziqubu Khanyisani K Tiano Luca L Silvestri Sonia S Orlando Patrick P Opoku Andy R AR Muller Christo J F CJF
PloS one 20190502 5
Aspalathin is a rooibos flavonoid with established blood glucose lowering properties, however, its efficacy to moderate complications associated with hepatic insulin resistance is unknown. To study such effects, C3A liver cells exposed to palmitate were used as a model of hepatic insulin resistance. These hepatocytes displayed impaired substrate metabolism, including reduced glucose transport and free fatty acid uptake. These defects included impaired insulin signaling, evident through reduced p ...[more]