Ontology highlight
ABSTRACT:
SUBMITTER: Lai YH
PROVIDER: S-EPMC6499532 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Genetics 20190322 1
RNA helicases are a class of enzymes that unwind RNA duplexes <i>in vitro</i> but whose cellular functions are largely enigmatic. Here, we provide evidence that the DEAD-box protein Dbp2 remodels RNA-protein complex (RNP) structure to facilitate efficient termination of transcription in <i>Saccharomyces cerevisiae</i> via the Nrd1-Nab3-Sen1 (NNS) complex. First, we find that loss of <i>DBP2</i> results in RNA polymerase II accumulation at the 3' ends of small nucleolar RNAs and a subset of mRNAs ...[more]