Ontology highlight
ABSTRACT:
SUBMITTER: Garner AL
PROVIDER: S-EPMC6512005 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20190422 5
In a high-throughput screening campaign, we recently discovered the rRNA-binding tetracyclines, methacycline and meclocycline, as inhibitors of Dicer-mediated processing of microRNAs. Herein, we describe our biophysical and biochemical characterization of these compounds. Interestingly, although direct, albeit weak, binding to the pre-microRNA hairpins was observed, the inhibitory activity of these compounds was not due to RNA binding. Through additional biochemical and chemical studies, we reve ...[more]