Ontology highlight
ABSTRACT:
SUBMITTER: Sheftel J
PROVIDER: S-EPMC6545696 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Sheftel Jesse J Surles Rebecca L RL Tanumihardjo Sherry A SA
Experimental biology and medicine (Maywood, N.J.) 20190319 7
<h4>Impact statement</h4>Vitamin A (VA) deficiency and hypervitaminosis A have been reported in groups of people worldwide. Conventional biomarkers of VA deficiency (e.g. serum retinol concentration, dose response tests) are not able to distinguish between sufficiency and hypervitaminosis A. Retinol isotope dilution (RID) predictions of VA status have been validated in humans and animal models from deficiency through toxicity; however, RID during life stages with unique issues related to isotopi ...[more]