Ontology highlight
ABSTRACT:
SUBMITTER: Cui WQ
PROVIDER: S-EPMC6558069 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in chemistry 20190604
Glutamine synthetase (GS), which catalyzes the production of glutamine, plays essential roles in most biological growth and biofilm formation, suggesting that GS may be used as a promising target for antibacterial therapy. We asked whether a GS inhibitor could be found as an anti-infective agent of <i>Staphylococcus xylosus</i> (<i>S. xylosus</i>). Here, computational prediction followed by experimental testing was used to characterize GS. Sorafenib was finally determined through computational p ...[more]