Guanidine Riboswitch-Regulated Efflux Transporters Protect Bacteria against Ionic Liquid Toxicity.

ABSTRACT: Plant cell walls contain a renewable, nearly limitless supply of sugar that could be used to support microbial production of commodity chemicals and biofuels. Imidazolium ionic liquid (IIL) solvents are among the best reagents for gaining access to the sugars in this otherwise recalcitrant biomass. However, the sugars from IIL-treated biomass are inevitably contaminated with residual IILs that inhibit growth in bacteria and yeast, blocking biochemical production by these organisms. IIL toxicity is, therefore, a critical roadblock in many industrial biosynthetic pathways. Although several IIL-tolerant (IIL^T) bacterial and yeast isolates have been identified in nature, few genetic mechanisms have been identified. In this study, we identified two IIL^TBacillus isol

SUBMITTER: Higgins DA 

PROVIDER: S-EPMC6560137 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature