Developing Picornaviruses for Cancer Therapy.
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ABSTRACT:
SUBMITTER: McCarthy C
PROVIDER: S-EPMC6562951 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Developing Picornaviruses for Cancer Therapy.
McCarthy Cormac C Jayawardena Nadishka N Burga Laura N LN Bostina Mihnea M
Cancers 20190516 5
Oncolytic viruses (OVs) form a group of novel anticancer therapeutic agents which selectively infect and lyse cancer cells. Members of several viral families, including <i>Picornaviridae</i>, have been shown to have anticancer activity. Picornaviruses are small icosahedral non-enveloped, positive-sense, single-stranded RNA viruses infecting a wide range of hosts. They possess several advantages for development for cancer therapy: Their genomes do not integrate into host chromosomes, do not encod ...[more]
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